Implementation of PM would include “a need for restructuring the healthcare system-detachment of healthcare professionals from the so-called organ-based specialties.” This study explores the experiences of the staff and patients involved in clinical research in personalized medicine. Even though central questions regarding research ethics (such as uncertainties about ensuring informed consent) remain, cancer patients, continue to enroll in personalized medicine research studies. Based on the research, we conclude that research design as well as legislative processes would benefit from inclusion of broad perspectives as expressed by those engaged in the experience of research as patients or as practitioners.Ĭontemporary advances in biomedical sciences related to genomic sequencing and molecular characterization are changing the landscape of cancer treatment and research at a fast pace. These results demonstrate that staff and patients both experience entanglement of research and care but they speak about the implementation process using disparate language. In the patient interviews, the following themes were discovered: personal narrative, autonomy, community, and relationships with staff. The staff interviews brought out the following themes: entanglement of research and care, professionality, context, scientific breakthrough, technocracy, and emotional engagement. The two sets of interviews were analyzed separately in a qualitative thematic analysis rooted in the theory of social constructionism. The six patient research subjects taking part in a prostate cancer PGM study were interviewed about their experiences. University hospital staff (n = 12) were interviewed concerning their views about the promises and challenges of the new medicine. This qualitative interview study explores the implementation of personalized genetic medicine (PGM) for prostate cancer in a major university hospital in Finland.
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